Click, Click, Bio Click

For me, 'click' means taking pictures; Or hear a 'click' sound when the seat belt is firmly attached to the buckle.
Three people who studied this sound in the field of chemistry since the beginning of 2000 have received the 2022 Nobel Prize in Chemistry - Carolyn Bertozzi, Morten Meldal, Barry Sharpless. Molecules joining together to form larger molecules is a WhatsApp Number List natural phenomenon. Water is made up of molecules of both hydrogen and oxygen. The salt we use contains sodium and chlorine together. Our blood contains 'hemoglobin' - a complex molecule formed by combining biogas, iron and a protein chain called globin.

There is a need to construct such conjugated molecules in laboratories. Fertilizers like urea, which are required in large quantities for industrial agriculture, are manufactured in large factories. They are aggregates of elements. Fritz Haber created ammonia by combining hydrogen and nitrogen. Then Carl Bosch established mass production. Despite the high demand, production consumes a lot of energy and pollutes the environment through waste. Hence the interest in producing 'Green Ammonia' arose.




In short, Barry said when he first bought the Nobel in 2001 that if we want to make industrially produced large molecules efficiently, cost-effectively and without waste, we need to leave the 'natural molecules' and try to synthesize them on a smaller scale. (Now available for the second time.) It plays a major role in the production of medicines. Carbon is present in the structure of organic molecules - but it is difficult to rearrange it to fit other molecules. So instead of this a small molecule (which also has carbon) can bridge oxygen or nitrogen atoms and get the same effect.


Linking molecules together is 'click chemistry'. The chemical effect of cycloaddition of azide and alkyne is called 'click chemistry'. For this we need to know a little about 1 'Azide' and 2 'Alkyne'. Azide is a polyatomic anion. Alkanes are isomeric compounds. Copper is commonly used as a catalyst in their synthesis. Clicking acid can be injected into the fiber to conduct electricity. This method is correct for inanimate objects. Copper ions (Copper ions) chemically react in living tissues and bring unwanted effects.



It was Caroline who wondered if this could be done to benefit living things. He investigated whether a specific glycon binds itself to lymph nodes. Glycan is an excellent carbohydrate. It is essential for many vital functions, from our immunity. A component of glycan is sialic acid. When azide was attached to a fluorescent molecule and injected into body tissue, it was possible to learn how the biomolecule travels through the tissue. It helps to deliver the drug directly to the affected tissue, especially for deadly diseases like cancer. Biomolecules (Biomolecules) are very important in pharmaceutical and medical field. For example, after antibodies bind to a tumor, A second molecule 'clicks' with that endogenous antagonist; It helps monitor the growth of the plaque; Or, if needed, to help direct the radiation to that area.